- Martín Almada, human rights activist and winner of the Alternative Nobel Prize
- Luis María Argaña, politician
- Eusebio Ayala, former president and writer
- Cecilio Báez, politician and writer
- Agustin Barrios-Mangoré, guitarist and composer
- Agustín Barrios, composer
- Augusto Roa Bastos, writer
- José Luis Chilavert, soccer player
- Arsenio Erico, soccer player
- Renée Ferrer de Arréllaga, writer
- José Asunción Flores, director and composer
- José Gaspar Rodríguez de Francia, first president
- Carlos Franco, professional golfer
- Julio César Franco, politician and former vice-president
- Nicanor Duarte Frutos, president of Paraguay
- Herminio Giménez, composer
- Sila Godoy, guitarist and composer
- Juan Natalicio González, former president and writer
- Julieta Granada, golfer
- Raúl Cubas Grau, politician and former president
- Nicolás Léoz, CONMEBOL president
- Carlos Antonio López, politician and former president
- Francisco Solano López, politician and former president
- Luis González Macchi, politician and former president
- Lino Oviedo, imprisoned former general & coup leader
- Victor Pecci, former tennis star
- Silvio Pettirossi, aviator
- Josefina Pla, poet
- Andrés Rodríguez, army general and former president
- Roque Santa Cruz, Professional footballer for FC Bayern Munich and Paraguay.
- Alfredo Stroessner, Former dictator of Paraguay
- Cindy Taylor, model
- Juan Carlos Wasmosy, Former president of Paraguay
