Arts
- Alfredo Sinclair, painter
- Carlos Francisco Chang Marín, folklorist, painter, musician, journalist, activist and writer
- José Luis Rodríguez Pittí, photographer
- Olga Sinclair, painter
Beauty
- Justine Pasek, Miss Universe 2002
- Rachel Smith, Miss USA 2007
Business
- Charles Patrick Garcia, businessman, author, leader
Entertainment
- Billy Cobham, drummer, Mahavishnu Orchestra
- Candice Michelle model, actress and WWE Diva (Half-Panamanian)
- Carlos Garnett, jazz saxophonist
- Danilo Pérez, jazz pianist
- Daphne Rubin-Vega, Broadway actress and singer
- El General, one of the forefathers of Reggaetón
- Ingrid De Ycaza, singer
- J. August Richards, actor
- Jaime Murrell, singer
- Jeff Buckley, singer-songwriter (half-Panamanian)
- Jordan & Jonathan Knight (former members of the New Kids on the Block) (half-Panamanian)
- Jordana Brewster, actress
- Los Rabanes, reggae-rock band
- Luis Russell, jazz musician and band director, first Panamanian international jazz musician
- Marc Anthony Thompson, musician, actor, film composer
- Melissa De Sousa, actress (The Best Man)
- Miguel Bosé, actor and singer
- Nancy Ames, singer (great-grandparents were of Panamanian descent)
- Nando Boom, Reggae artist
- Rubén Blades, Salsa music singer, Hollywood actor, former Presidential candidate, Minister of Tourism
- Vincent Laresca, actor
History
- Bayano, rebel slave
- Belisario Porras, President
- Edward Ashton Gaskin Stuart, educator and labour leader
- Floyd Britton, leftist, believed to had been murdered during the Black Years of the various Panamanian dictatorships
- Luis Anderson McNeil, former Minister of Labor of the Republic of Panama
- Norma Mascoll, the first female US Director of Engineering and Housing (DEH)
- Urracá, indigenous cacique
- Victoriano Lorenzo, patriot
Literature
- Gloria Guardia novelist, essayist
- José Luis Rodríguez Pittí, writer, photographer
- Rosa María Britton, writer
Politics
- Arnulfo Arias Madrid, former President
- Belisario Porras, former President
- Ernesto Pérez Balladares, former President
- Esteban Huertas, independence fighter
- Guillermo Endara, former President
- Harmodio Arias Madrid, former President
- Jorge Illueca diplomat and politician
- Julio E. Linares Treasury Minister (1963-1964) and Foreign Minister (1989-1993)
- Manuel Antonio Noriega, dictator
- Martín Torrijos Espino, President (Current)
- Omar Torrijos Herrera, National Guard and nation's leader
Science
- Kenneth Bancroft Clark, psychologist, writer
Sports
- Ben Oglivie, MLB baseball player
- Bruce Chen, MLB baseball player
- Carlos Lee, baseball player
- Danilo Pinnock, basketball shooting guard
- Einar Díaz, MLB baseball player
- Eusebio Pedroza, world champion boxer
- Felipe Baloy, defender
- Hilario Zapata, world champion boxer
- Jaime Penedo goalkeeper
- Jorge Dely Valdes, forward
- José Macías, MLB baseball player
- Juan Berenguer, MLB baseball player
- Julio César Dely Valdes, forward
- Laffit Pincay Jr., world class jockey
- Lloyd LaBeach, first Olympic medal holder of Panama
- Luis Tejada, forward
- Mariano Rivera, New York Yankees pitcher
- Olmedo Sáenz, MLB baseball player
- Omar Moreno, MLB baseball player
- Orlando Miller, MLB baseball player
- Oscar Willis Layne, Cyclist during the 1930s, 40s and 50s
- Ramiro Mendoza, NY Yankees, Boston Red Sox, Pitcher
- Reginald Beckford, sprinter, 100 and 200 metres, first gold medallist of Panama
- Rennie Stennett, MLB baseball player
- Roberto Corbin, forward (First Panamanian to play in Europe)
- Roberto Durán, 4 times world boxing champion
- Roberto Kelly, baseball player
- Roberto Vásquez, world champion boxer
- Rod Carew, hall of fame baseball player
- Rolando Blackman, Former NBA basketball player
- Rommel Fernandez, forward
- Rubén Rivera, MLB baseball player
- Stuart Gray, NBA Player
- William Bedford, NBA Player
